Powder dosing and filling

ITCM are specialists in the precision dosing and filling of powders, granules and infusion products. We are particularly skilled at working with substances which are difficult to handle, such as those which are sticky and highly cohesive or fine and delicate. We also specialise in maintaining a uniform mixture for products that tend to segregate during processing. We have significant experience dosing pharmaceutical powders for multi-dose and reservoir inhalers, analgesics, black, green and herbal teas, coffee, food ingredients and many others.

We understand that the same dosing method is not suitable for all products. A vital element of our work is studying product characteristics and behaviour. Our rigorous approach to laboratory sampling and bench testing helps determine the tolerances of the product and identifies the ideal process parameters and operating ranges for the manufacturing environment. The impact of product variation on key processing steps will be quantified to ensure a robust manufacturing process and high production yield. If, for example, a controlled environment for humidity in the dosing suite is necessary, then this requirement will form part of the design early on.

Precision powder dosing machines

We are recognised as a global leader in the development of new and novel solutions for the precision dosing and filling of powders. Our expertise lies in the ability to dose over a wide range of weights and ingredient characteristics. We have developed processes for micro-dose weights from 1.00mg – 20.00mg for precise pharmaceutical processes. Other applications include fill weights ranging from 2g – 1000g for coffee, tea, chocolate and other food products.

ITCM has also developed systems for continuous blending and dispensing of ingredients, providing solutions to significantly reduce cycle times and in-process inventory.

Delicate powder handling

We have experience handling delicate powders and ensuring product integrity throughout the dosing process. Maintaining the chemical structure of the product is essential. Active ingredients are often fragile and need to be stabilized with an excipient, or inactive ingredient. Sometimes the bond to the excipient is fragile, calling for very careful handling of the product. For example, excess shaking, large impacts or compressions can cause serious damage to these powders, often rendering the active ingredient ineffective. ITCM is familiar with these challenges and works closely with our customers to ensure that their products reach the consumer in perfect condition.

Maintaining the proper mixture of ingredients is also key. Products with multiple powders and differing particle sizes and weights tend to separate during processing. For these products the mixture in each dose is critical. ITCM has experience handling these products, maintaining uniformity and ensuring consistent proportions in each dose.

The following case studies provide more information on powder dosing at ITCM:

• Micro-dosing powders into blisters
• Powder dosing into a high-speed glassine web